Cellular function and control of volume-regulated anion channels |
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Authors: | Jan Eggermont Dominique Trouet Iris Carton Bernd Nilius |
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Institution: | (1) Laboratory of Physiology, Catholic University of Leuven, Campus Gasthuisberg, B-3000 Leuven, Belgium |
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Abstract: | Restoration of cell volume after cell swelling in mammalian cells is achieved by the loss of solutes (K+, Cl−, and organic osmolytes) and the subsequent osmotically driven efflux of water. This process is generally known as regulatory
volume decrease (RVD). One pathway for the swelling induced loss of Cl− (and also organic osmolytes) during RVD is the volume-regulated anion channel (VRAC). In this review, we discuss the physiological
role and cellular control of VRAC. We will first highlight evidence that VRAC is more than a volume regulator and that it
participates in other fundamental cellular processes such as cell proliferation and apoptosis. The second part concentrates
on the Rho/Rho kinase/myosin phosphorylation cascade and on compartmentalization in caveolae as modulators of the signal transduction
cascade that controls VRAC gating in vascular endothelial cells. |
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Keywords: | Chloride channel cell volume RhoA caveola tyrosine kinase |
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