Studies on chromatin |
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Authors: | A. J. Varshavsky V. V. Bakayev |
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Affiliation: | 1. Institute of Molecular Biology, Academy of Sciences of the U.S.S.R., Moscow, USSR
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Abstract: | Chromatin lacking histone H1 was found by electron microscopy to contain 'beaded' deoxyribonucleoprotein fibers. Adjacent beads are connected with each other by threads having a DNA-like appearance. At least some of threads are shown to be free DNA stretches. Average length and the content of free DNA stretches in histone H1-depleted chromatin depends on the ionic conditions of the medium. The appearance of individual beads is similar to that of chromatin subunits or v-bodies [1] in the original chromatin. Thus, in agreement with the X-ray data [2], histone H1 apparently is not required for maintenance of a compact state of DNA in chromatin subunits. |
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