Coevolution of the mammalian chemokines and their receptors |
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Authors: | Austin L Hughes Meredith Yeager |
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Institution: | (1) Department of Biology and Institute of Molecular Evolutionary Genetics, 208 Mueller Laboratory, The Pennsylvania State University, University Park PA 16802, USA, US |
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Abstract: | A phylogeny of mammalian chemokines revealed two major clusters, corresponding to the CC and CXC chemokines; the C chemokines
appeared to be more closely related to the former. In a phylogeny of chemokine receptors, there were also two major clusters:
one containing CC chemokine receptors plus other receptors of unknown function and another containing CXC receptors and other
receptors of unknown function. However, within the CC receptors, there was not a close correspondence between the phylogenies
of chemokines and their receptors. The CC chemokines contained two major subfamilies: (1) the MIP subfamily (including MIP-1α,
MIP-1β, and RANTES); and (2) the MCP subfamily (including MCP-1,-2,-3, and -4 and eotaxin). Receptors having preferred ligands
in the MCP subfamily did not constitute a monophyletic group but rather evolved twice independently. Reconstruction of ancestral
amino acid sequences suggested that these two groups of MCP receptors did not convergently evolve any amino acid residues;
rather, they convergently lost sequence features found in the third and fourth extracellular domains of known receptors for
MIP-subfamily chemokines.
Received: 1 May 1998 / Revised: 3 July 1998 |
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Keywords: | Coevolution Mammalian cytokines Receptors |
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