The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6
+/- mouse model of epithelial wound-healing delay |
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| Authors: | Lucy J Leiper Petr Walczysko Romana Kucerova Jingxing Ou Lynne J Shanley Diane Lawson John V Forrester Colin D McCaig Min Zhao Martin J Collinson |
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| Institution: | (1) School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, AB25 2ZD Aberdeen, UK |
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| Abstract: | Background Congenital aniridia caused by heterozygousity at the PAX6 locus is associated with ocular surface disease including keratopathy. It is not clear whether the keratopathy is a direct
result of reduced PAX6 gene dosage in the cornea itself, or due to recurrent corneal trauma secondary to defects such as dry eye caused by loss
of PAX6 in other tissues. We investigated the hypothesis that reducing Pax6 gene dosage leads to corneal wound-healing defects. and assayed the immediate molecular responses to wounding in wild-type
and mutant corneal epithelial cells. |
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