The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization |
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| Authors: | Erin E Baschal Kuan J Chen Lee G Elliott Matthew J Herring Shawn C Verde Tom D Wolkow |
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| Institution: | (1) Department of Biology, University of Colorado at Colorado Springs, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80918, USA |
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| Abstract: | Background DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon
detecting checkpoint signals such as stalled replication forks or double-stranded DNA breaks, these pathways coordinate appropriate
stress responses. Members of the PI-3 kinase related kinase (PIKK) family are essential elements of DNA structure checkpoints.
In fission yeast, the Rad3 PIKK and its regulatory subunit Rad26 coordinate the detection of checkpoint signals with pathway
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