Expression of carbonic anhydrases IX and XII during mouse embryonic development |
| |
| Authors: | Heini Kallio Silvia Pastorekova Jaromir Pastorek Abdul Waheed William S Sly Susanna Mannisto Markku Heikinheimo Seppo Parkkila |
| |
| Affiliation: | (1) Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN-33520, Biokatu 8, Tampere, Finland;(2) Center of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic;(3) Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, USA;(4) Children's Hospital and Program for Developmental and Reproductive Biology, University of Helsinki, Helsinki, Finland;(5) Department of Pediatrics, Washington University, St. Louis, Missouri, USA;(6) Department of Clinical Chemistry, University of Oulu, Oulu, Finland |
| |
| Abstract: | Background Of the thirteen active carbonic anhydrase (CA) isozymes, CA IX and XII have been linked to carcinogenesis. It has been suggested that these membrane-bound CAs participate in cancer cell invasion, which is facilitated by an acidic tumor cell environment. Since active cell migration is a characteristic feature of embryonic development, we set out to explore whether these isozymes are expressed in mouse embryos of different ages. The studies were focused on organogenesis stage. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
