Predicting the effect of missense mutations on protein function: analysis with Bayesian networks |
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| Authors: | Chris J Needham James R Bradford Andrew J Bulpitt Matthew A Care David R Westhead |
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| Institution: | (1) School of Computing, University of Leeds, Leeds, LS2 9JT, UK;(2) Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK |
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| Abstract: | Background A number of methods that use both protein structural and evolutionary information are available to predict the functional
consequences of missense mutations. However, many of these methods break down if either one of the two types of data are missing.
Furthermore, there is a lack of rigorous assessment of how important the different factors are to prediction. |
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