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The X-ray Crystal Structure of the First RNA Recognition Motif and Site-Directed Mutagenesis Suggest a Possible HuR Redox Sensing Mechanism |
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| Authors: | Roger Marc Benoit Patrick Graff Régis Cèbe Hans Widmer |
| Institution: | 1 Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, 4056 Basel, Switzerland 2 University of Edinburgh, School of Biological Sciences, The King's Buildings, CH Waddington Building 3.07, Mayfield Road, Edinburgh EH9 3JR, UK |
| Abstract: | |
| Keywords: | HuR Hu-antigen R RRM RNA recognition motif ARE AU-rich element PDB Protein Data Bank SEC size-exclusion chromatography MALS multiangle light scattering PTB polypyrimidine tract binding VHL von Hippel Lindau VEGF vascular endothelial growth factor |
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