Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage. |
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| Authors: | K Chapman Z Mustafa C Irven A J Carr K Clipsham A Smith J Chitnavis J S Sinsheimer V A Bloomfield M McCartney O Cox L R Cardon B Sykes and J Loughlin |
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| Institution: | Wellcome Trust Centre for Human Genetics, Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom. |
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| Abstract: | We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM. Sixteen markers that showed evidence of linkage at nominal P
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