Riboflavin production by <Emphasis Type="Italic">Ashbya gossypii</Emphasis> |
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Authors: | Tatsuya Kato Enoch Y Park |
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Institution: | (1) Department of Applied Biological Chemistry, Shizuoka University, 836 Ohya Suruga-ku, Shizuoka 422-8529, Japan;(2) Graduate School of Science and Technology, Shizuoka University, 836 Ohya Suruga-ku, Shizuoka 422-8529, Japan |
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Abstract: | Riboflavin is an important nutrient for humans and animals. Industrial production has shifted completely from chemical synthesis
to microbial fermentation. First generation riboflavin production was improved by a combination of traditional mutagenesis
and genetic engineering, and isolated strains have been used in industry. As the DNA genome of riboflavin producers has the
potential to reveal new technologies, DNA microarray, proteomic and metabolic analyses have been applied to the analysis of
hyper-riboflavin producers. In this review, disparity mutagenesis technology is introduced as a means of improving riboflavin
production by Ashbya gossypii. DNA microarray, proteomic and metabolic analyses of this high riboflavin producer are discussed, as well as recent riboflavin
production trends, costs and future improvements. |
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Keywords: | |
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