Choline acetyltransferase activity of spinal cord cell cultures is increased by diisopropylphosphorofluoridate.期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Choline acetyltransferase activity of spinal cord cell cultures is increased by diisopropylphosphorofluoridate.

Authors:	N Brookes A M Goldberg

Institution:	1. Department of Pharmacology & Experimental Therapeutics University of Maryland School of Medicine Baltimore, Maryland 21201, USA;2. Department of Environmental Health Sciences The Johns Hopkins University School of Hygiene Baltimore, Maryland 21205, USA

Abstract:	Diisopropylphosphorofluoridate (DFP) increased the specific activity of choline acetyltransferase (ChAT) in mouse spinal cord cell cultures but paraoxon did not, though both toxicants inhibited cholinesterase activity to a comparable extent. This effect of DFP was observed after prolonged exposure but not after short-term application to the cultures. It is postulated that this delayed effect of DFP $in vitro$ may possibly be related tothe delayed neuropathy caused by DFP in certain species $in vivo$ .

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