Analysis of 6-keto-prostaglandin F1α in human urine: Age-specific differences |
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| Authors: | Burkhard Scherer Sven Fischer Wolfgang Siess Peter C Weber |
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| Institution: | Medizinische Klinik Innenstadt der Universität München, Ziemssenstrasse 1, 8 Munich 2, FRG |
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| Abstract: | A radioimmunoassay (RIA) for the estimation of 6-keto-PGF1α in human urine is described in detail. The RIA method was validated by direct comparison to gas chromatography-mass spectrometry. In adults and in one year old children basal excretion of 6-keto-PGF1α was found to be lower than that reported for PGE2 or PGF2α. However, during the first week of life, significantly more 6-keto-PGF1α was excreted. The very high levels of 6-keto-PGF1α in urine seen on the third day of life seemed already to decrease during the first week of life. It is concluded that prostacyclin may have a major role for kidney function in the newborn, possibly by protecting the immature kidney from high levels of angiotensin II. |
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