Collagen formation and calcification in teleost scales

Summary Electron microscopy of scales from the marine teleost Hippoglossoides elassodon (Pleuronectidae) indicates a morphological and functional similarity to bone and teeth in that a cellular layer apparently deposits collagen fibers which increase in diameter in extracellular locations. The collagen fibers form layers with fiber axes alternating at approximately 90° in the plane of the scale so that the overall structure resembles plywood. The evidence suggests that the matrix between the fibers becomes more concentrated, finally crystallizing by the deposition of material resembling hydroxyapatite located between and within the collagen fibers.This investigation was supported by Public Health Service research grant CA 08158 from the National Cancer Institute.