Rate of disappearance of isethionic acid in the rat central nervous system |
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Authors: | J B Lombardini Jacqueline A Homan |
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Institution: | (1) Department of Pharmacology and Therapeutics, Texas Tech University School of Medicine, 79430 Lubbock, Texas |
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Abstract: | The rates of disappearance of tritiated isethionic acid (2-hydroxyethanesulfonic acid) in eight regions of the rat central nervous system were studied. By utilizing the technique of graphical analysis ( curve peeling ), it was determined that seven areas (striatum, diencephalon, pons-medulla, midbrain, hippocampus, spinal cord, and cortex) exhibited triphasic (fast, intermediate, and slow) disappearance rates while only the cerebellum displayed a biphasic (fast, slow) rate. The half-lives for the fast component in the different regions of the central nervous system varied from 0.5 hr (midbrain and cortex) to 1.5 hr (diencephalon, cerebellum, and spinal cord); the half-lives for the intermediate component of the triphasic rate varied from 3.5 hr in the midbrain and spinal cord to 5.5 hr in the hippocampus. Half-lives estimated for the slow component of the multiphasic rate of disappearance of tritiated isethionic acid (3H]ISA) varied from 28 hr (cerebellum) to 90 hr (spinal cord). |
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