A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR) |
| |
| Authors: | Maija R J Kohonen-Corish Yao Wang William F Doe |
| |
| Institution: | (1) Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, GPO Box 334, 2601 Canberra, ACT, Australia |
| |
| Abstract: | We describe the first highly polymorphic microsatellite marker for the human urokinase plasminogen activator receptor gene (PLAUR). The urokinase receptor (uPAR) has a central role in cancer invasion and metastasis, which may enable the development of new anti-metastatic therapies. Analysis of the marker genotypes in colorectal cancer cell lines revealed three alleles that were not detected in a series of healthy control individuals, which encourages further genetic study of the role of uPAR in cancer. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
