Induction of antimicrobial peptide synthesis by fat body cells in Calliphora vicina R.-D. (diptera, calliphoridae) larvae

The fat body is the main place of synthesis if peptide antibiotics in insects. The goal of the present study was the search in the body of the larva Calliphora vicina for humoral factors inducing synthesis of antimicrobial peptides by fat body cells during trauma. The preliminary analysis has shown that the activation factor revealed in hemolymph is the thermostable hydrophilic compound with molecular mass less than 3 kDa. According to results of experiments, the integument epitheliocytes and hemocytes also release the humoral factors directly stimulating synthesis of antimicrobial peptides by fat body.