| 红斑性肢痛症相关痘病毒血清免疫学特征的研究 |
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| 引用本文： | 郑志明,张江虹.红斑性肢痛症相关痘病毒血清免疫学特征的研究[J].Virologica Sinica,1992,7(1):54-58. |
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| 作者姓名： | 郑志明 张江虹 |
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| 作者单位： | 湖北医学院病毒研究所,湖北医学院病毒研究所,湖北医学院病毒研究所,湖北医学院病毒研究所,美国南佛罗里达大学医学院 武汉,武汉,武汉,武汉,Tampa,FL |
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| 摘 要： | 本文从四个方面综合报道了红斑性肢痛症相关痘病毒(ERPV)血清免疫学特征的研究结果。血清学鉴定表明,ERPV为正痘病毒属内成员,但与正痘病毒属内成员痘苗病毒和鼠痘病毒具有中和抗原表位差异。流行性红斑性肢痛症患者血清中含有抗ERPV的中和抗体和抗ERPVA型包涵体IgG抗体,其检出率明显高于当地未发病者和美国人群的检出率。
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| 关 键 词： | 红斑性肢痛性 痘病毒 血清学 |
Studies on the Serological Properties of Erythromelalgia--Related Poxvirus |
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| Zheng Zhi-ming,Zhang Jian-hong,Cai An-mei,Zhu Wei-ping,Steven Specier,Herman Friedman Virus Research Institute,Hubei Medical University,Wuhan Departmen of Medical Microbiology and Immunolgy,University of South Florida,Tampa,Florida,USA.Studies on the Serological Properties of Erythromelalgia--Related Poxvirus[J].中国病毒学(英文版),1992,7(1):54-58. |
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| Authors: | Zheng Zhi-ming Zhang Jian-hong Cai An-mei Zhu Wei-ping Steven Specier Herman Friedman Virus Research Institute Hubei Medical University Wuhan Departmen of Medical Microbiology and Immunolgy University of South Florida Tampa Florida USA |
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| Institution: | Zheng Zhi-ming,Zhang Jian-hong,Cai An-mei,Zhu Wei-ping,Steven Specier,Herman Friedman Virus Research Institute,Hubei Medical University,Wuhan 430071 Departmen of Medical Microbiology and Immunolgy,University of South Florida,Tampa,Florida,USA |
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| Abstract: | The serological reactivity of erythromelalgia-related poxvirus (ERPV)which originally was isolated from the throab swab of a patient with eryhth-romelalgia was analyzed in the present study. Rabbits immunized by foot-padinoculation of ERPV started to produce neutralizing (NT) antibody to ERPVat 2 weeks postinfection (p. i.). The peak NT antibody titers were observedat 4 weeks p. i. and then began to decline. When eight antisera including sheepanti-Orf, bovine anti-parapox, rabbit antivaccinia, rhesus monkey anti-Tanapox,rabbit anti-Yabapox, raccoon anti-raccoonpox, human anti-molluscum contagio-sum, and mouse antiectromelia virus were used to identify 6 ERPV isolates,only rabbit anti-vaccinia, mouse anti-ectromelia, and rabbit anti-ERPV anti-sera reacted with all isolate. Thus, ERPV was serologically identified as anorthopoxvirus. However, when rabbit anti-ERPV antisera were useed to cross-neutralize vaccinia or ectromelia virus, neither was neutralized by these anti-sera, suggesting that there are some epitope differences in NT antigens bet-ween ERPV, vaccinia and ectromelia. Furthermore, 68% (17/25) of thepatients with a history of epidemic erythromelalgia and only 25% (2/8) of non-disesed control subjects tested positive for anti-ERPV antibody in their serausing a plaque reduction NT test. In addition, the detection of anti-ERPVIgG using immunofluorescence was significant higher (P<0.005) in the serafrom patients with epidemic erythromelalgia (49/125, 39.2%) as comparedwith the sera controls (2/17, 11.8%)or "American" controls (5/42, 11.9%). |
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| Keywords: | Erythromelalgia Poxvirus Serological assay |
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