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基于熵准则的鲁棒的RBF谷胱甘肽发酵建模
引用本文:谭左平,王士同,邓赵红,堵国成. 基于熵准则的鲁棒的RBF谷胱甘肽发酵建模[J]. 生物工程学报, 2008, 24(5): 829-836
作者姓名:谭左平  王士同  邓赵红  堵国成
作者单位:江南大学信息工程学院,江南大学工业技术教育部重点实验室,无锡,214122
基金项目:国家863资助项目(No. 2007AA1Z158, 2006AA10Z313); 国家自然科学基金资助项目(No. 60773206/F020106, 60704047/F030304); 2004年教育部跨世纪优秀人才支持计划基金项目(NO. NCET-04-0496), 2006年江苏省6大人才高峰计划资助项目, 南京大学软件新技术国家重点实验室开放课题。
摘    要:在谷胱甘肽的发酵过程建模中, 当试验数据含有噪音时, 往往会导致模型预测精度和泛化能力的下降。针对该问题, 提出了一种新的基于熵准则的RBF神经网络建模方法。与传统的基于MSE准则函数的建模方法相比, 新方法能从训练样本的整体分布结构来进行模型参数学习, 有效地避免了传统的基于MSE准则的RBF网络的过学习和泛化能力差的缺陷。将该模型应用到实际的谷胱甘肽发酵过程建模中, 实验结果表明: 该方法具有较高的预测精度、泛化能力和良好的鲁棒性, 从而对谷胱甘肽的发酵建模有潜在的应用价值。

关 键 词:谷胱甘肽   相对熵   RBF神经网络   Parzen窗法   鲁棒性
收稿时间:2007-10-08
修稿时间:2007-10-08

GSH Fermentation Process Modeling Using Entropy-criterion Based RBF Neural Network Model
Zuoping Tan,Shitong Wang,Zhaohong Deng and Guocheng Du. GSH Fermentation Process Modeling Using Entropy-criterion Based RBF Neural Network Model[J]. Chinese journal of biotechnology, 2008, 24(5): 829-836
Authors:Zuoping Tan  Shitong Wang  Zhaohong Deng  Guocheng Du
Affiliation:Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Information Engineering, Jiangnan University, Wuxi 214122, China;Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Information Engineering, Jiangnan University, Wuxi 214122, China;Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Information Engineering, Jiangnan University, Wuxi 214122, China;Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Information Engineering, Jiangnan University, Wuxi 214122, China
Abstract:The prediction accuracy and generalization of GSH fermentation process modeling are often deteriorated by noise existing in the corresponding experimental data. In order to avoid this problem, we present a novel RBF neural network modeling approach based on entropy criterion. It considers the whole distribution structure of the training data set in the parameter learning process compared with the traditional MSE-criterion based parameter learning, and thus effectively avoids the weak generalization and over-learning. Then the proposed approach is applied to the GSH fermentation process modeling. Our results demonstrate that this proposed method has better prediction accuracy, generalization and robustness such that it offers a potential application merit for the GSH fermentation process modeling.
Keywords:GSH   relative entropy   RBF neural network   Parzen window   robustness
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