Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles |
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| Authors: | Srilakshmi M Sharma Dongseok Choi Stephen R Planck Christina A Harrington Carrie R Austin Jinnell A Lewis Tessa N Diebel Tammy M Martin Justine R Smith James T Rosenbaum |
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| Affiliation: | (1) Casey Eye Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA;(2) Department of Public Health & Preventive Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA;(3) Department of Cell & Developmental Biology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA;(4) Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA;(5) Gene Microarray Shared Resource, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA;(6) Department of Molecular Microbiology & Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA |
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| Abstract: | Introduction Axial spondyloarthropathy (SpA) is a group of inflammatory diseases, with ankylosing spondylitis as the prototype. SpA affects the axial skeleton, entheses, joints and, at times, the eyes. This study tested the hypothesis that SpA is characterized by a distinct pattern of gene expression in peripheral blood of affected individuals compared with healthy controls. |
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