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Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet |
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| Authors: | Vincent Corbel Maria Stankiewicz Cédric Pennetier Didier Fournier Jure Stojan Emmanuelle Girard Mitko Dimitrov Jordi Molgó Jean-Marc Hougard Bruno Lapied |
| Affiliation: | 1. Laboratoire de Lutte contre les Insectes Nuisibles, Institut de Recherche pour le Développement, F-34 394, Montpellier, France 3. Institut de Recherche pour le Développement/Centre de Recherches Entomologiques de Cotonou, 01 BP 4414, République du Bénin 2. Institute of General & Molecular Biology, N. Copernicus University, 87-100, Torun, Poland 4. Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM), UPRES EA 2647/USC INRA 2023, IFR 149 QUASAV, Université d'Angers, UFR Sciences, F-49045, Angers cedex, France 5. Groupe de Biotechnologie des protéines, Université de Toulouse, Toulouse, France 6. Institute of Biochemistry, Medical Faculty, University of Ljubljana, Slovenia 7. Laboratoire de Neurobiologie Cellulaire et Moléculaire – UPR9040, CNRS, Institut de Neurobiologie Alfred Fessard – FRC2118, Gif sur Yvette, F-91198, France |
| Abstract: | BackgroundN,N-Diethyl-3-methylbenzamide (deet) remains the gold standard for insect repellents. About 200 million people use it every year and over 8 billion doses have been applied over the past 50 years. Despite the widespread and increased interest in the use of deet in public health programmes, controversies remain concerning both the identification of its target sites at the olfactory system and its mechanism of toxicity in insects, mammals and humans. Here, we investigated the molecular target site for deet and the consequences of its interactions with carbamate insecticides on the cholinergic system. |
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