Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells |
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| Authors: | Qing-wen Chen Lars Edvinsson Cang-Bao Xu |
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| Affiliation: | (1) Division of Experimental Vascular Research, Institute of Clinical Science in Lund, Lund University, Lund, Sweden;(2) Department of Clinical and Experimental Research, Glostrup Hospital, Copenhagen University, Copenhagen, Denmark |
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| Abstract: | Background Endothelin-1 (ET-1) is a potent vasoactive peptide, which induces vasoconstriction and proliferation in vascular smooth muscle cells (VSMCs) through activation of endothelin type A (ETA) and type B (ETB) receptors. The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein kinases (MAPK) are involved in ET-1-induced VSMC contraction and proliferation. This study was designed to investigate the ETA and ETB receptor intracellular signaling in human VSMCs and used phosphorylation (activation) of ERK1/2 as a functional signal molecule for endothelin receptor activity. |
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