Orthologous gene-expression profiling in multi-species models: search for candidate genes |
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| Authors: | Dmitry N Grigoryev Shwu-Fan Ma Rafael A Irizarry Shui Qing Ye John Quackenbush Joe GN Garcia |
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| Institution: | Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, East Monument Street, Baltimore, MD 21287, USA. |
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| Abstract: | Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes. |
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