The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs |
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| Authors: | Amour Augustin Knight C Graham English William R Webster Ailsa Slocombe Patrick M Knäuper Vera Docherty Andrew J P Becherer J David Blobel Carl P Murphy Gillian |
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| Affiliation: | Department of Food Science Research for Health, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan. yano@nih.go.jp |
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| Abstract: | Prostaglandin E2 (PGE2)-dependent effects on various cell responses are regulated by respective PGE2 receptors (EP1, EP2, EP3, EP4) expressing in target cells. Alveolar type II cell (a main progenitor cell of lung adenocarcinoma) expressed only EP4, while human lung adenocarcinoma cells (A549) expressed EP3 as well as EP4. An antagonistic effect of EP3 against EP4 through the modulation of cyclic AMP level is required for PGE2-mediated activation of Ras signal pathway in A549 cells. These results suggest that the expression of EP3 may be a critical factor for the PGE2-mediated activation of Ras signal pathway in A549 cells. |
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