Synthesis and structure-affinity relationships at the central benzodiazepine receptor of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines. |
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| Authors: | F Campagna F Palluotto A Carotti G Casini G Genchi |
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| Institution: | Dipartimento Farmacochimico, Università di Bari, Italy. campagna@farmchim.uniba.it |
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| Abstract: | A series of 2-aryl-3-chloro-2H-pyridazino4,3-b]indoles, 2-aryl-3-methoxy-2H-pyridazino4,3-b]indoles, and 2-aryl-2,5-dihydroindeno1,2-c]pyridazino-3(3H)-ones has been prepared and tested for their ability to inhibit the 3H]flunitrazepam binding to the central benzodiazepine receptor. SAR are presented and discussed in comparison with existing pharmacophore models. |
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