Improved entrapment of drugs in modified liposomes

Incorporation of 8-azaguanine and 6-mercaptopurine into single compartment dipalmitoyl-DL-α-phosphatidylcholine liposomes has been increased dramatically by the presence of chloranil transfer complex formation. The enhanced entrapment is due to charge. The charge transfer complex readily decomposes to the parent donor drug and chloranil acceptor. Chloranil, however, may be toxic. Using 3,5-dinitrobenzoyl-n-butylamide and 3,5-dinitrobenzoyl phosphatidylethanolamine as electron donors did not result in enhanced entrapments.