Amphetamine-induced release of dopamine from the substantia nigra |
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Authors: | Charles Paden Charles J Wilson Philip M Groves |
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Institution: | Department of Psychology and Institute for Behavioral Genetics University of Colorado Boulder, Colorado 80309, USA |
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Abstract: | Incubation of chopped tissue from the substantia nigra of the rat brain with d-amphetamine resulted in a significant release of 3H]dopamine into the incubation medium. This effect was observed with both exogenous 3H]dopamine previously taken up by the tissue and 3H]dopamine endogenously synthesized from L-3,5-3H]tyrosine. The observed release was greater in magnitude when the apparent conversion of released dopamine to 3-methoxytyramine was taken into account. The relevance of the present results to the previously postulated self-inhibition by dopaminergic neurons of the substantia nigra pars compacta is discussed. The present data also provide support for the concept that catechol-O-methyltransferase (E.C.2.1.1.6.) is located primarily extraneuronally in brain. |
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Keywords: | Reprints may be obtained from Philip M Groves Department of Psychology University of Colorado Boulder Colorado 80309 |
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