Somatostatin in the physiologic feedback control of thyrotropin secretion |
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| Authors: | Pornpun Tanjasiri Xenia Kozbur Warner H. Florsheim |
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| Affiliation: | 1. Medical Research Service U.S. Veterans Administration Hospital Long Beach, California 90822, U.S.A.;2. Chemistry Department, California State University, Long Beach, USA;3. University of California, Irvine, USA |
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| Abstract: | The addition of an antiserum against Somatostatin (SRIF) to a culture of dispersed rat pituitary cells incubated in the presence of hypothalamic tissue enhances thyrotropin (TSH) secretion into the medium. This indicates that SRIF is normally secreted in amounts sufficient to affect TSH secretion and suggests that SRIF may be the agent responsible for the unexplained rapid termination of TSH secretion by thyrotrophs which have been activated by Thyrotropin Releasing Factor (TRF). |
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