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Multivariate genome-wide association studies on tenderness of Berkshire and Duroc pig breeds
Authors:Dongsung Jang  Joon Yoon  Mengistie Taye  Wonseok Lee  Taehyung Kwon  Seunghyun Shim  Heebal Kim
Institution:1.Interdisciplinary Program in Agricultural Genomics,Seoul National University,Seoul,Republic of Korea;2.Department of Natural Science, Interdisciplinary Program in Bioinformatics,Seoul National University,Seoul,Republic of Korea;3.Department of Agricultural Biotechnology, Animal Biotechnology and Research Institute of Agriculture and Life Sciences,Seoul National University,Seoul,Republic of Korea;4.College of Agriculture and Environmental Sciences,Bahir Dar University,Bahir Dar,Ethiopia;5.LAS Inc.,Gimpo-si,Republic of Korea;6.Institute for Biomedical Sciences,Shinshu University,Nagano,Japan
Abstract:Genome-wide association studies (GWAS) have been steadily used for identification of genomic links to disease and various economical traits. Of those traits, a tenderness of pork is one of the most important factors in quality evaluation of consumers. In this study, we use two pig breed populations; Berkshire is known for its excellent meat quality and Duroc which is known for its high intramuscular fat content in meat. Multivariate genome-wide association studies (MV-GWAS) was executed to compare SNPs of two pigs to find out what genetic variants occur the tenderness of pork. Through MV-GWAS, we have identified candidate genes and the association of biological pathways involved in the tenderness of pork. From these direct and indirect associations, we displayed the usefulness of simple statistical models and their potential contribution to improving the meat quality of pork. We identified a candidate gene related to the tenderness in only Berkshire. Furthermore, several of the biological pathways involved in tenderness in both Berkshire and Duroc were found. The candidate genes identified in this study will be helpful to use them in breeding programs for improving pork quality.
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