Morphine dependent rats: Blockade of precipitated abstinence by calcium |
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| Authors: | I.S. Sanghvi S. Gershon |
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| Affiliation: | Neuropsychopharmacology Research Unit Department of Psychiatry New York University School of Medicine New York, N.Y. 10016, USA |
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| Abstract: | In rats made dependent on morphine, brain levels of calcium were significantly lowered. Naloxone administration to such rats produced characteristic abstinence signs. Prior treatment with calcium markedly reduced naloxone-induced abstinence signs and prevented morphine-induced lowering of brain calcium. It is suggested that the antagonistic actions of calcium and morphine may be related to their effects on morphine-sensitive adenylate cyclase activity. |
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