Stimulation of serum lecithin-cholesterol acyltransferase activity by phenobarbital in the rat |
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| Authors: | Robert L Russell Carlos Soler-Argilaga Murray Heimberg |
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| Institution: | Department of Pharmacology, School of Medicine University of Missouri Columbia, Missouri 65201, USA |
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| Abstract: | The activity of serum lecithin-cholesterol acyltransferase was increased on administration of phenobarbital to the rat. This effect was dependent on dose and elapsed time after administration of the drug. Phenobarbital did not stimulate lecithin-cholesterol acyltransferase activity when added to serum from normal animals in vitro. Presumably, phenobarbital increased serum lecithin-cholesterol acyltransferase activity by induction of the microsomal enzyme and subsequent secretion by the liver. |
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