Identifying candidate positive selection genes in Korean imported pig breeds |
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| Authors: | Wonseok Lee Mengistie Taye Taehyung Kwon Joon Yoon Dongsung Jang Shunsuke Suzuki Heebal Kim |
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| Institution: | 1.Department of Agricultural Biotechnology, Animal Biotechnology and Research Institute of Agriculture and Life Sciences,Seoul National University,Seoul,Republic of Korea;2.Bahir Dar University, College of Agriculture and Environmental Sciences,Bahir Dar,Ethiopia;3.Department of Natural Science, Interdisciplinary Program in Bioinformatics,Seoul National University,Seoul,Republic of Korea;4.Interdisciplinary Program in Agricultural Genomics,Seoul National University,Seoul,Republic of Korea;5.Epigenomics Division, Frontier Agriscience and Technology Center, Faculty of Agriculture,Shinshu University,Nagano,Japan;6.Department of Interdisciplinary Genome Sciences and Cell Metabolism, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research,Shinshu University,Nagano,Japan;7.Institute for Biomedical Sciences,Shinshu University,Nagano,Japan |
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| Abstract: | Domestication and artificial selection have modified the genome landscape of the pig. The identification of selection signatures in the genome can help to elucidate the selection mechanisms and uncover the causal genes related to the phenotypic variations between domestic pig breeds. We scanned the genomes of Korean imported pig breeds against native breeds using Z-transformed Fst (ZFST) and Heterozygosity (ZHp) statistics to search for the signatures of positive selection. We identified 411 (ZFST?=?175; ZHp?=?256) putatively selected genes in commercial breeds. The gene regions identified were harboring those related to immunity, coat color, reproduction function and other traits. Several genes (e.g., PLSCR4, AGTR1 and CORIN) were related to reproduction traits such as fertility, ovulation rate, and uterine function. This study revealed genes which improve our understanding of the biological mechanisms of higher litter sizes, the phenotype of interest, in higher litter pig breeds. |
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