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Long interspersed element-1 open reading frame 1 protein expression profiles in ovarian cancers
Authors:Ka Yeong Yun  Eun Ji Ko  Heung Yeol Kim  Ji Young Lee  Wan Kyu Eo  Mee Sun Ock  Heui-Soo Kim  Ki Hyung Kim  Hee-Jae Cha
Institution:1.Department of Medicine,Pusan National University School of Medicine,Busan,Republic of Korea;2.Department of Parasitology and Genetics,Kosin University College of Medicine,Busan,Republic of Korea;3.Department of Obstetrics and Gynecology,Kosin University College of Medicine,Busan,Republic of Korea;4.Department of Obstetrics and Gynecology,Konkuk University School of Medicine,Seoul,Republic of Korea;5.Department of Internal Medicine,Kyung Hee University,Seoul,Republic of Korea;6.Department of Biological Sciences,Pusan National University,Busan,Republic of Korea;7.Department of Obstetrics and Gynecology,Pusan National University School of Medicine,Busan,Republic of Korea;8.Biomedical Research Institute and Pusan Cancer Center,Pusan National University Hospital,Busan,Republic of Korea
Abstract:Long interspersed element-1 (LINE-1) retrotransposons are autonomous mobile DNA elements with unique activity that account for about one-fifth of the human genome. Recently, it has been reported that the expression of LINE-1 is closely related to cancer prognosis, and LINE-1 hypomethylation might contribute to the acquisition of aggressive tumor behavior. Despite the importance of LINE-1 expression in cancers, research on the expression of LINE-1 open reading frame (ORF) proteins is very limited. Here, we investigated the expression profiles of LINE-1 ORF1p in ovarian cancer tissue microarrays containing 100 surgical specimens including adjacent normal ovary tissue, primary ovarian cancers, and metastatic ovarian cancers in lymph node. The tissue microarray was stained with mouse monoclonal antibody to LINE-1 ORFp1 for immunofluorescence analysis, and expression levels were evaluated by image analysis. LINE-1 ORFp was significantly overexpressed in ovarian cancers compared with normal tissues and especially upregulated in metastatic ovarian cancers. In addition, the expression of LINE-1 ORF1p was significantly higher in older ovarian cancer patients compared with young patients. These results indicate that expression of LINE-1 ORF1p is related to the progression of ovarian cancers and, in particular, to the age of the patient and the metastatic potential of the cancer.
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