CEACAM1 recognition by bacterial pathogens is species-specific |
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| Authors: | Maike Voges Verena Bachmann Robert Kammerer Uri Gophna Christof R Hauck |
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| Affiliation: | 1.Lehrstuhl für Zellbiologie,Universit?t Konstanz,Konstanz,Germany;2.Konstanz Research School Chemical Biology,Universit?t Konstanz,Konstanz,Germany;3.Institute of Immunology,Friedrich-L?ffler-Institut,Tübingen,Germany;4.Department of Molecular Microbiology and Biotechnology,Tel Aviv University,Tel Aviv,Israel |
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| Abstract: | Background Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), an immunoglobulin (Ig)-related glycoprotein, serves as cellular receptor for a variety of Gram-negative bacterial pathogens associated with the human mucosa. In particular, Neisseria gonorrhoeae, N. meningitidis, Moraxella catarrhalis, and Haemophilus influenzae possess well-characterized CEACAM1-binding adhesins. CEACAM1 is typically involved in cell-cell attachment, epithelial differentiation, neovascularisation and regulation of T-cell proliferation, and is one of the few CEACAM family members with homologues in different mammalian lineages. However, it is unknown whether bacterial adhesins of human pathogens can recognize CEACAM1 orthologues from other mammals. |
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