颌下腺表皮生长因子促进大鼠胃粘膜损伤的愈合

用免疫组织化学方法观察到雄性大鼠颌下腺有非常丰富的表皮生长因子样免疫活性物质，并且主要位于导管细胞中，颌下腺摘除使血清尤其是胃液ＥＧＦ水平显著降低，直至手术后第２８天仍然维持在较低水平。利用颌下腺摘除术清内源性ＥＧＦ后，冰乙酸涂抹造成的慢性胃溃疡愈合速度较假手术大鼠明显减慢，而补充相应剂量的外源性ＥＧＦ可使颌下腺摘除大鼠的溃疡愈合速度恢复到与假手术组引当水平。上述结果显示，颌下腺及其分泌的ＥＧＦ对

SUBMAXILLARY GLAND EPIDERMAL GROWTH FACTOR ACCELERATED HEALING OF CHRONIC GASTRIC MUCOSAL LESIONS IN RATS

Large amount of EGF--like immunoreactivity was observed in the submandibulargland of rats with immunohistichemical method. The staining is mainly localized inthe ductal cells. The level of EGF in gastric juice and serum was measured with a spe-cific and sensitive RIA method. It was observed that EGF level was decreased both ingastric juice and in serum after sialoadenectomy and subsequent healing of chronic gastric ulcer induced by serosal acetic acid was delayed. Oral administration of EGF tosiaioadenectomized rats could reverse the lowered rate of ulcer healing to almost nor-mal level. The above results suggested that secretion of EGF may have an importanteffect on the healing of chronic gastric lesions in rats.