Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations |
| |
Authors: | Selma Čorović Mojca Pavlin Damijan Miklavčič |
| |
Institution: | (1) Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia |
| |
Abstract: | Background Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses
to introduce chemotherapeutic drugs into tumor cells or genes into target cells based on the cell membrane electroporation.
The main focus of this paper was to calculate analytically and numerically local electric field distribution inside the treated
tissue in two dimensional (2D) models for different plate and needle electrode configurations and to compare the local electric
field distribution to parameter U/d, which is widely used in electrochemotherapy and gene electrotransfer studies. We demonstrate the importance of evaluating
the local electric field distribution in electrochemotherapy and gene electrotransfer. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |