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Lasiodiplodin,a potent antileukemic macrolide from Euphorbia splendens |
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| Authors: | Kuo-Hsiung Leet Nanao Hayashi Masayoshi Okano Iris H. Hall Rong-Yang Wu Andrew T. Mcphailti |
| Affiliation: | 1. Department of Medicinal Chemistry, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27514, U.S.A.;2. Institute of Botany, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China;3. Paul M., Gross Chemical Laboratory, Duke University, Durham, NC 27706, U.S.A. |
| Abstract: | In vivo P-388 assay-directed fractionation of an active extract from Euphorbia splendens has led to the isolation of lasiodiplodin, a potent antileukemic macrolide, the structure of which was established from spectral data and a single-crystal X-ray analysis. |
| Keywords: | Euphorbiaceae lasiodiplodin NMR X-ray antileukemic macrolide. |
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