Synthesis and antihyperglycemic activity profiles of novel thiazolidinedione derivatives |
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| Authors: | Bhat Bashir A Ponnala Shashikanth Sahu Devi Prasad Tiwari Priti Tripathi Brajendra K Srivastava Arvind K |
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| Affiliation: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A number of thiazolidine-2,4-diones derivatives having carboxylic ester appendage at N-3 were synthesized and their antihyperglycemic activity was evaluated. Many of these derivatives as well as their corresponding carboxylic acid showed significant improvement on post-prandial hyperglycemia in normal rats, in contrast to their poor agonist activity at PPARgamma. |
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