Actin stress fiber retraction and aggresome formation is a common cellular response to actin toxins |
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| Authors: | Kazami Sayaka Usui Takeo Osada Hiroyuki |
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| Institution: | Chemical Library Validation Team, Chemical Biology Core Facility, RIKEN Advanced Science Institute, Saitama. |
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| Abstract: | F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins. |
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