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Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators |
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| Authors: | Link J T Sorensen Bryan K Patel Jyoti Arendsen David Li Gaoquan Swanson Susan Nguyen Bach Emery Maurice Grynfarb Marlena Goos-Nilsson Annika |
| Affiliation: | Metabolic Disease Research, Abbott Laboratories, Dept 4CB, Bldg. AP-10, Rm. L-14, 100 Abbott Park Road, Abott Park, IL 60064-6098, USA. james.link@abbott.com |
| Abstract: | The optimization of a series of nonsteroidal glucocorticoid modulators is reported. Potent selective GR ligands that have improved metabolic stability were discovered typified by the subnanomolar acid 12 (GR binding IC(50)=0.6 nM). |
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| 本文献已被 PubMed 等数据库收录！ | |