糖化血清白蛋白检测对2型糖尿病患者短期血糖控制的疗效评价

目的：探讨糖化血清白蛋白（glycate dalbumin, GA）作为反映近期（2 周内）血糖控制总体水平的指标在糖尿病人群中的临床应用价值。方法：选取2010 年6 月-2013 年7 月间深圳市福田区中医院住院的2 型糖尿病（T2DM）患者323 例，测定空腹血糖（FPG）、餐后2 小时血糖（2hPG）、1 日指尖血糖谱均值（MBG）、GA、糖化血红蛋白（HbAlc）等，并对其中92 例住院近2 周的患者分别在入院后6 天及12 天复查上述指标。结果：GA 与HbAlc（r=0.791），FPG（r=0.541），2hPG（r=0.456），MBG（r=0.401），均呈正相关（P 均〈0.01）；患者入院6 天检测GA 为（27.1± 5.45）％，入院12 天为（22.77± 4.34）％，均显著低于入院第一天的（30.31±6.75）％（P〈0.01）；入院6 天和12 天，患者的GA 较入院时分别下降3.12％和7.54％（P〈0.01）；HbAlC 分别下降0.31％和0.78％，GA下降降幅显著大于HbAlc（P〈0.01）。结论：GA可及时、准确的反映短期（1～2 周）平均血糖的变化情况，并与长期血糖控制的金标准HbAlC 有良好的相关性，是监测糖尿病患者血糖控制的良好指标。

Detection of Glycated Albumin on the Evaluation of Short Term Glycemic Control for Patients with Type 2 Diabetes

Objective： To investigate the clinical value of glycated albumin reflective indicator of the general monitoring standard of blood glucose in the diabetics patients. Methods： 323 patients with Type 2 Diabetes Mullites （T2DM） who were treated in our hospital between June 2010 and July 2013 were enrolled in the study. The fasting plasma-glucose （FPG）, two-hours＇ postprandial blood glucose （2hPG）, MGB, GA and HbAlc of patients were detected and evaluated. The above parameters were measured again respectively on the 6th and the 12th day. Results： A positive relation of GA value, HbAlc, FPG, 2hPG and MBG was found with the coefficient index of 0.791, 0.541, 0.456 and 0.401, respectively （P〈0.01）; On the 6th day afler the admission, the mean level of GA in the 92 patients was （27.1 ± 5.45）%, and the 12th day was（22.77± 4.34）% that were both significantly lower than （30.31 ± 6.75）% in the first day（P〈0.01）; After the admission for 6 and 12 days, the GA level of patients decreased in 3.12% and 7.54%, respectively（P〈0.1）, when compared with that of the first day; The HbAlc level was decreased in 0.31% and 0.78%, respectively（P〈0.1）. The decreasing degree of GA was greater than that of HbA1c （P〈0.01）. Conclusion： The level of GA can reflect the short-term changes of the mean level of blood glucose in an immediate and exact way. Meanwhile, it was well correlated with HbA1C which was the gold standard of long-term diabetic controUing, as well as a good indicator for monitoring blood glucose control of the diabetic patients.