Terpenes with antimicrobial activity from Cretan propolis |
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| Authors: | Milena P Popova Ioanna B Chinou Ilko N Marekov Vassya S Bankova |
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| Institution: | aInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Bl. 9, 1113 Sofia, Bulgaria;bDivision of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, University of Athens, Greece |
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| Abstract: | Five terpenes, the diterpenes: 14,15-dinor-13-oxo-8(17)-labden-19-oic acid and a mixture of labda-8(17),13E-dien-19-carboxy-15-yl oleate and palmitate as well as the triterpenes, 3,4-seco-cycloart-12-hydroxy-4(28),24-dien-3-oic acid and cycloart-3,7-dihydroxy-24-en-28-oic acid were isolated from Cretan propolis. Moreover, 18 known compounds were also isolated, seven of them for the first time as propolis components. All structures were established on the basis of spectroscopic analysis and chemical evidence. All isolated compounds were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria as well as against some human pathogenic fungi showing a broad spectrum of antimicrobial activity. |
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| Keywords: | Cretan propolis Diterpenes Triterpenes Fatty acid diterpenoic esters Flavonoid glycoside Antimicrobial activity |
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