Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections |
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| Institution: | 1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia;2. Central Research Institute of Epidemiology of the Federal Service on Customers'' Rights Protection and Human Well-Being Surveillance, ul. Novogireevskaya 3a, Moscow, 111123, Russia;3. Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi per. 5a, Moscow, 105064, Russia;1. Laboratory for Clinical Research on Infectious Disease, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;2. Department of Respiratory Medicine, Allergy and Rheumatic Disease, Graduate School of Medicine, Osaka University, Osaka, Japan;3. Department of Pediatrics, Nishi-Kobe Medical Center, Kobe, Japan;4. Division of Control and Treatment of Infectious Diseases, Chiba University Hospital, Chiba, Japan;5. Department of Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan;6. Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan;7. National Mie Hospital, Mie, Japan;8. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan;9. Infectious Disease Surveillance Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjyuku, Tokyo 162-8640, Japan;1. Laboratory of Medical Investigation Unit 56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo, Brazil;2. Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo, Brazil;3. Tropical Medicine Institute, University of São Paulo, São Paulo, Brazil |
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| Abstract: | Immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from N. meningitidis serogroup B were detected. Thus, the cross-reactive protection against meningococcal and pneumococcal infections has been demonstrated in vivo. Presumably it indicates the presence of common epitopes in the N. meningitidis IgA1 protease and S. pneumoniae surface proteins. |
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| Keywords: | IgA1 protease Meningococcal vaccines Epitopes |
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