Antimicrobial activity and chemical composition of essential oil from Helichrysum microphyllum Cambess. subsp. tyrrhenicum Bacch., Brullo & Giusso collected in South-West Sardinia |
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Affiliation: | 1. Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy;2. Institute of Biomolecular Chemistry, National Research Council (CNR), 07100 Sassari, Italy;3. Department od Internal Medicine, Azienda Sanitaria Provinciale di Enna, 94100 Enna, Italy;4. Department of Natural and Land Sciences, University of Sassari, 07100 Sassari, Italy |
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Abstract: | The aim of this study was to evaluate the chemical composition and the antimicrobial activity of essential oils of Helichrysum microphyllum subsp. tyrrhenicum collected in four different stations in South-Western Sardinia.The composition of the essential oils was determined by gas chromatography and gas chromatography/mass spectrometry. The oil samples showed different chromatographic profiles. The oil of the station 4 revealed the presence of significant amount of neryl acetate (33.6%); in oils from stations 1 and 2 we found γ-curcumene (28%) and in station 3 γ-curcumene (12%) and linalool (11%), while there was no trace of neryl acetate. Standard microbiological assays demonstrated that essential oils obtained by plants collected in station 1 and 2, very rich in curcumene, showed an interesting anticandidal activity, dose- and time-dependent, which is enhanced by sub-inhibitory concentrations of chitosan.Our results suggest that the essential oil of Helichrysum microphyllum subsp. tyrrhenicum, associated with chitosan in innovative formulations, could be considered as a therapeutic alternative in the treatment of Candida opportunistic infections. The results of this study shows that the chemotypization of the species examined could lead to their targeted clinical use, in a concept of a rational scientific aromatherapy. |
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Keywords: | Essential oil composition Curcumene Antimicrobial activity Anticandidal activity Chitosan |
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