Regulatory Properties of Adenylyl Cyclase Isoforms

Various aspects of mechanisms of the adenylyl cyclase (AC)* activity regulation are considered in the review. Variants of modulation of various AC isoform activity by G-proteins (_s- and _i subunits, -dimer), Ca²⁺-calmodulin, phosphorylation by PKA, PKC or Ca²⁺-CM-activated kinases are presented. Evidence is presented that AC functions as a signaling integrator in the cell by providing propagation and amplification of many both extracellular (with participation of hormones) and intracellular signals (interaction between Ca²⁺ and AC).