The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity |
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Authors: | Giménez Diana Andreu Cecilia del Olmo Marcel lí Varea Teresa Diaz Dolores Asensio Gregorio |
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Institution: | Departament de Química Orgànica, Facultat de Farmàcia, Universitat de València, 46100 Burjassot, València, Spain. |
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Abstract: | The effect of introducing fluorine atoms or trifluoromethyl groups in either the peptidic chain or the C-terminal end of cationic pentapeptides is reported. Three series of amide and ester peptides were synthesised and their antimicrobial properties evaluated. An enhanced activity was found in those derivatives whose structure contained fluorine, suggesting an increase in their hydrophobicity. |
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