Oriented cell divisions and muscle satellite cell heterogeneity |
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Authors: | Cossu Giulio Tajbakhsh Shahragim |
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Institution: | Stem Cell Research Institute, Dibit, San Raffaele, Via Olgettina 58, 20132 Milan, Italy. cossu.giulio@hsr.it |
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Abstract: | Satellite cells are crucial for maintaining muscle homeostasis and for regeneration following injury. In this issue, Kuang et al. (2007) reveal that muscle satellite cells are a heterogeneous mixture of stem cells and committed myogenic progenitors. They show that asymmetric division of stem cells in the satellite cell niche is a mechanism for generating these two populations. |
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