Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction |
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| Authors: | J Goverman K Minard N Shastri T Hunkapiller D Hansburg E Sercarz L Hood |
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| Institution: | 1. Division of Biology California Institute of Technology Pasadena, California 91125 USA;2. Department of Pathology Fox Chase Cancer Center Philadelphia, Pennsylvania 19111 USA;3. Department of Microbiology University of California, Los Angeles Los Angeles, California 90024 USA |
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| Abstract: | The helper T cell clone 3H.25 is specific for hen egg white lysozyme and the class II MHC molecule I-Ab. This TH cell has three rearrangements in the beta-chain gene family-a V beta-D beta-J beta 1 and a D beta 2-J beta 2 rearrangement on one homolog and a D beta 1-J beta 2 rearrangement on the other. These observations demonstrate that this functional T lymphocyte expresses only a single V beta gene segment and, accordingly, exhibits allelic exclusion of beta-chain gene expression. The rearranged 3H.25 V beta gene segment is the same as that expressed in a T helper cell specific for cytochrome c and an I-Ek MHC molecule. Thus, there is no simple correlation between the V beta gene segment and antigen specificity or MHC restriction. |
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