Comparative efficacy of amphotericin B,clotrimazole and itraconazole againstAspergillus spp. |
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| Authors: | Young H Hahn Donald G Ahearn PhD Louis A Wilson |
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| Institution: | (1) Department of Ophthalmology, Kosin Medical College, Pusan, Korea;(2) Laboratory for Microbial and Biochemistry Sciences, Georgia State University, Atlanta, Georgia, USA;(3) Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA;(4) Department of Biology, Georgia State University, P.O. Box 4010, 30302-4010 Atlanta, GA, USA |
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| Abstract: | The susceptibilities of two isolates ofAspergillus flavus, one from a human case of recalcitrant mycotic keratitis, and an environmental isolate ofA. fumigatus, to itraconazole, clotrimazole and amphotericin B were measured. Observations of macroscopic growth and microscopic evaluations of conidia germination both indicated that the two isolates ofA. flavus were markedly more resistant to amphotericin B than to itraconazole and clotrimazole. Itraconazole was more effective than clotrimazole for all isolates. Ourin vitro susceptibility results suggest the use of itraconazole should be a primary consideration in the treatment ofAspergillus keratitis. |
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| Keywords: | Amphotericin B Aspergillus spp Clotrimazole In vitro susceptibility Itraconazole |
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