Regulation of phenylacetic acid degradation genes of Burkholderia cenocepacia K56-2 |
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| Authors: | Jason NR Hamlin Ruhi AM Bloodworth Silvia T Cardona |
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| Affiliation: | (1) Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada;(2) Current address : Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada |
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| Abstract: | Background Metabolically versatile soil bacteria Burkholderia cepacia complex (Bcc) have emerged as opportunistic pathogens, especially of cystic fibrosis (CF). Previously, we initiated the characterization of the phenylacetic acid (PA) degradation pathway in B. cenocepacia, a member of the Bcc, and demonstrated the necessity of a functional PA catabolic pathway for full virulence in Caenorhabditis elegans. In this study, we aimed to characterize regulatory elements and nutritional requirements that control the PA catabolic genes in B. cenocepacia K56-2. |
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