A point mutation in the core subunit gene of yeast mitochondrial RNA polymerase is suppressed by a high level of specificity factor MTF1 |
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Authors: | Wolfgang Schuster Bruno Combettes Karin Flieger and Axel Brennicke |
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Institution: | (1) Institut für Genbiologische Forschung, Ihnestrasse 63, W-1000 Berlin 33, Germany;(2) Present address: IBMP, 12 rue du General Zimmer, F-67084 Strasbourg, France;(3) Present address: Botanisches Institut, Universität München, Menzinger Strasse 67, W-8000 München 19, Germany |
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Abstract: | Analysis of a transcribed region in the mitochondrial genome of Oenothera revealed an open reading frame (ORF) of 577 codons (orf577) that is also conserved in carrot, here encoding a protein of 579 amino acids (orf579). RNA editing alters the mRNA sequence of orf577 in Oenothera with 46 C to U transitions, many of which improve sequence similarity with the homologous Marchantia gene orf509. The deduced polypeptides show significant similarity with the ccll-encoded protein involved in cytochrome c biogenesis in the photosynthetic bacterium Rhodobacter capsulatus. A highly conserved domain is also found in plastid ORFs, suggesting that these bacterial, chloroplast and mitochondrial genes encode polypeptides with analogous functions in assembly and maturation of cytochromes c. |
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Keywords: | Plant mitochondria Cytochrome c assembly Chloroplasts ccl1 |
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